Vitamin D is now known to be linked to over 200 different genes, in that its presence or deficiency can impact the way that those genes operate.  These genes include several which are related to some cancers as well as autoimmune conditions such as multiple sclerosis, type 1 diabetes, rickets, Crohn’s disease and even dementia.

This link between Vitamin D and DNA occurs within the vitamin D receptors (VDRs) which connect with various parts in specific places along the human genome. This leads doctors to believe that Vitamin D plays an exceptionally important role in preventing this type of disease as well as in achieving the best possible health.

These beliefs are not without clinical support.  More than eight hundred studies have shown that vitamin D is effective in the prevention of cancer.  In fact, research is saying that by ensuring that you receive the right amount of vitamin D and by avoiding deficiencies in this nutrient, you can reduce the risk of some cancers by fifty percent and reduce the chances of developing diabetes or heart disease by forty three percent.

Vitamin D is even known to support the gene that regulates the ability to fight chronic inflammation as well as infections. It encourages the body to produce more than two hundred anti-microbial peptides, such as cathelicidin, which is a broad-spectrum antibiotic which occurs naturally in the body.

Unfortunately, new studies are indicating that 85 percent of Americans are deficient in vitamin D.  Experts are encouraging people to speak to their doctors about whether or not they are vitamin D deficient and how to increase their vitamin D levels if it is necessary.

Sources:

• http://www.foodconsumer.org/newsite/Nutrition/Vitamins/cancer_diabetes_0609100640.html
• http://www.mb.com.ph/articles/274802/sunshine-vit-d-influences-more-200-genes

The safety of the popular diabetes drug Avandia (rosiglitazone), manufactured by Glaxo, has been called into question by Food and Drug Administration (FDA) staff scientists and the drug was recently placed at risk for a massive recall.  The result of the vote by the FDA panel after a two-day meeting with the endocrinologic and metabolic advisory committees which ended July 14, 2010, was to keep the drug available to the U.S. Market but with significant new restrictions. Most importantly, stronger warnings regarding the cardiovascular risks surrounding the use of Avandia.

The drug’s safety has been in question since 2007, the last time the FDA considered taking it off the market in the United States when a dozen studies showed worrying data regarding the safety of Avandia in response to a 2005 analysis which linked the drug to an increase in heart attacks by 43 percent.  This new labeling could reduce the use of Avandia by 95 percent.

The risks associated with diabetes medications are leading people to look into effective alternative treatments of their condition, such as the recent vitamin D3 and sunlight therapies that are shown in important studies to be quite effective.  For example, the recent study by endocrinologist Esther Krug, MD, from Baltimore’s Sinai Hospital (as well as assistant professor of medicine at Johns Hopkins University School of Medicine) showed that over 90 percent of patients with type 2 diabetes were vitamin D3 deficient and that the greater the deficiency, the worse the diabetic condition.  Those findings support previous studies that have linked insulin production cells and the production of the insulin itself with vitamin D3.

Vitamin D can have an impact on glycemic control, so diabetic patients should discuss adding vitamin D3 to their diets through proper nutrition, supplements, and exposure to sunlight or full-spectrum lighting.

Sources:

• http://online.wsj.com/article/BT-CO-20100709-708932.html
• http://news.sciencemag.org/scienceinsider/2010/07/fda-panel-gives-avandia.html
• http://online.wsj.com/article/SB10001424052748704682604575369232879016248.html?mod=googlenews_wsj
• http://www.diabeteshealth.com/read/2010/07/04/6747/vitamin-d-deficiency-common-in-people-with-poor-diabetes-control-/